There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription. Central metabolic pathways are under the control of signalling pathways and, vice versa, the cellular metabolic profile influences cell signalling through the incorporation of various metabolic sensors into the signalling networks. Thus information about nutrients availability directly and crucially influences crucial cell decisions. In the present review, I summarize our current knowledge of various metabolic sensors and give some examples of the integration of metabolically derived inputs into the signalling system and the regulation of transcription. I also discuss the Warburg effect where the cross-talk between metabolism and signalling is used to orchestrate rapid cell growth and division. It is becoming clear that future research will concentrate on the collection of small-molecule metabolites, whose concentration fluctuates in response to cellular energy levels, searching for their sensors that connect them to the signalling and transcriptional networks.
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April 2012
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Conference Article|
March 21 2012
Metabolic sensors and their interplay with cell signalling and transcription
Alena Krejčí
Alena Krejčí
1
1University of South Bohemia, Branišovská 31, České Budějovice, 370 05, Czech Republic, and Biology Centre, Czech Academy of Sciences, Institute of Entomology, Branišovská 31, České Budějovice, 370 05, Czech Republic
1emailakrejci@prf.jcu.cz
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Biochem Soc Trans (2012) 40 (2): 311–323.
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December 14 2011
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Alena Krejčí; Metabolic sensors and their interplay with cell signalling and transcription. Biochem Soc Trans 1 April 2012; 40 (2): 311–323. doi: https://doi.org/10.1042/BST20110767
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