A major question in chromatin biology is to what extent the sequence of DNA directly determines the genetic and chromatin organization of a eukaryotic genome? We consider two aspects to this question: the DNA sequence-specified positioning of nucleosomes and the determination of NDRs (nucleosome-depleted regions) or barriers. We argue that, in budding yeast, while DNA sequence-specified nucleosome positioning may contribute to positions flanking the regions lacking nucleosomes, DNA thermodynamic stability is a major component determinant of the genetic organization of this organism.
DNA structure, nucleosome placement and chromatin remodelling: a perspective
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Andrew A. Travers, Cédric Vaillant, Alain Arneodo, Georgi Muskhelishvili; DNA structure, nucleosome placement and chromatin remodelling: a perspective. Biochem Soc Trans 1 April 2012; 40 (2): 335–340. doi: https://doi.org/10.1042/BST20110757
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