TERS (tip-enhanced Raman scattering) provides exceptional spatial resolution without any need for labelling and has become a versatile tool for biochemical analysis. Two examples will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c, leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule analysis is discussed, again based on TERS experiments on DNA and RNA, further highlighting the resolution capabilities of this method.
Advances in TERS (tip-enhanced Raman scattering) for biochemical applications
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Regina Treffer, René Böhme, Tanja Deckert-Gaudig, Katherine Lau, Stephan Tiede, Xiumei Lin, Volker Deckert; Advances in TERS (tip-enhanced Raman scattering) for biochemical applications. Biochem Soc Trans 1 August 2012; 40 (4): 609–614. doi: https://doi.org/10.1042/BST20120033
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