SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.
SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer
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Elaine A. Hong, Hannah L. Gautrey, David J. Elliott, Alison J. Tyson-Capper; SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer. Biochem Soc Trans 1 August 2012; 40 (4): 826–830. doi: https://doi.org/10.1042/BST20120030
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