Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.
Analysis of urinary microRNAs in chronic kidney disease
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Cristina Beltrami, Aled Clayton, Aled O. Phillips, Donald J. Fraser, Timothy Bowen; Analysis of urinary microRNAs in chronic kidney disease. Biochem Soc Trans 1 August 2012; 40 (4): 875–879. doi: https://doi.org/10.1042/BST20120090
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