Intracellular pathogens survive in eukaryotic cells by evading a variety of host defences. To avoid degradation through the endocytic pathway, intracellular bacteria must adapt their phagosomes into protective compartments that promote bacterial replication. Legionella pneumophila and Coxiella burnetii are Gram-negative intracellular pathogens that remodel their phagosomes by co-opting components of the host cell, including Rab GTPases. L. pneumophila and C. burnetii are related phylogenetically and share an analogous type IV secretion system for delivering bacterial effectors into the host cell. Some of these effectors mimic eukaryotic biochemical activities to recruit and modify Rabs at the vacuole. In the present review, we cover how these bacterial species, which utilize divergent strategies to establish replicative vacuoles, use translocated proteins to manipulate host Rabs, as well as exploring which Rabs are implicated in vacuolar biogenesis in these two organisms.
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December 2012
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Conference Article|
November 21 2012
The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii Available to Purchase
Camille A. Hardiman;
Camille A. Hardiman
1Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, U.S.A.
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Justin A. McDonough;
Justin A. McDonough
1Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, U.S.A.
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Hayley J. Newton;
Hayley J. Newton
1Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, U.S.A.
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Craig R. Roy
Craig R. Roy
1
1Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, U.S.A.
1To whom correspondence should be addressed (email[email protected]).
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Publisher: Portland Press Ltd
Received:
July 20 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1353–1359.
Article history
Received:
July 20 2012
Citation
Camille A. Hardiman, Justin A. McDonough, Hayley J. Newton, Craig R. Roy; The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii. Biochem Soc Trans 1 December 2012; 40 (6): 1353–1359. doi: https://doi.org/10.1042/BST20120167
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