Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely in the hypervariable C-terminus is incorrect, and a second mechanism involving a GDF [GDI (guanine-nucleotide-dissociation inhibitor) displacement factor] to disrupt stable Rab–GDI complexes has only been shown to apply in one case, despite the need for targeting over 60 human Rab proteins. Evidence for the involvement of Rab–effector interactions has only been presented for a few cases or in a very specific context. There is mounting evidence that GEFs (guanine-nucleotide-exchange factors) are essential for membrane targeting, although contributions from additional factors are likely to be of importance, at least in specific cases.
Conference Article| November 21 2012
Specific localization of Rabs at intracellular membranes
Roger S. Goody;
Aymelt Itzen 1
*Max-Planck-Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn-Strasse 6, Dortmund 44227, Germany
†Center for Integrated Protein Science Munich, Chemistry Department, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany
1To whom correspondence should be addressed (firstname.lastname@example.org).
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Julia Blümer, Yao-Wen Wu, Roger S. Goody, Aymelt Itzen; Specific localization of Rabs at intracellular membranes. Biochem Soc Trans 1 December 2012; 40 (6): 1421–1425. doi: https://doi.org/10.1042/BST20120225
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