Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely in the hypervariable C-terminus is incorrect, and a second mechanism involving a GDF [GDI (guanine-nucleotide-dissociation inhibitor) displacement factor] to disrupt stable Rab–GDI complexes has only been shown to apply in one case, despite the need for targeting over 60 human Rab proteins. Evidence for the involvement of Rab–effector interactions has only been presented for a few cases or in a very specific context. There is mounting evidence that GEFs (guanine-nucleotide-exchange factors) are essential for membrane targeting, although contributions from additional factors are likely to be of importance, at least in specific cases.
Skip Nav Destination
Article navigation
December 2012
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 21 2012
Specific localization of Rabs at intracellular membranes Available to Purchase
Julia Blümer;
Julia Blümer
*Max-Planck-Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn-Strasse 6, Dortmund 44227, Germany
Search for other works by this author on:
Yao-Wen Wu;
Yao-Wen Wu
*Max-Planck-Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn-Strasse 6, Dortmund 44227, Germany
Search for other works by this author on:
Roger S. Goody;
Roger S. Goody
*Max-Planck-Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn-Strasse 6, Dortmund 44227, Germany
Search for other works by this author on:
Aymelt Itzen
Aymelt Itzen
1
*Max-Planck-Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn-Strasse 6, Dortmund 44227, Germany
†Center for Integrated Protein Science Munich, Chemistry Department, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany
1To whom correspondence should be addressed (email[email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 31 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1421–1425.
Article history
Received:
August 31 2012
Citation
Julia Blümer, Yao-Wen Wu, Roger S. Goody, Aymelt Itzen; Specific localization of Rabs at intracellular membranes. Biochem Soc Trans 1 December 2012; 40 (6): 1421–1425. doi: https://doi.org/10.1042/BST20120225
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Get Email Alerts
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |