The release of extracellular vesicles, whether MVs (microvesicles) or exosomes, from host cells or intracellular pathogens is likely to play a significant role in the infection process. Host MVs may fuse with pathogen surfaces to deliver host complement regulatory proteins. They may also deliver cytokines that enhance invasion. Decoy functions are also possible. Whereas host MVs may direct pathogens away from their target cells, pathogen MVs may in turn redirect complement membrane-attack complexes away from their target pathogen. An understanding of the mechanisms of this interplay, bringing about both immune evasion and enhanced invasion, will help to direct future research with a view to rendering pathogens more susceptible to immune attack or in improving drug efficacy. It should also be possible to use MVs or exosomes isolated directly from the pathogens, or from the cells infected with pathogens, to provide alternative vaccination strategies.
Skip Nav Destination
Article navigation
February 2013
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
January 29 2013
Interplay of host–pathogen microvesicles and their role in infectious disease
Jameel M. Inal;
Jameel M. Inal
1
*Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166–220 Holloway Road, London N7 8DB, U.K.
1Correspondance may be addressed to either of these authors (emailj.inal@londonmet.ac.uk or s.lange@ucl.ac.uk).
Search for other works by this author on:
Ephraim A. Ansa-Addo;
Ephraim A. Ansa-Addo
†Department of Immunobiology and Cancer Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, U.S.A.
Search for other works by this author on:
Sigrun Lange
Sigrun Lange
1
‡Perinatal Brain Repair Group, Maternal & Foetal Medicine, Institute for Women's Health, University College London, 86–96 Chenies Mews, London WC1E 6HX, U.K.
1Correspondance may be addressed to either of these authors (emailj.inal@londonmet.ac.uk or s.lange@ucl.ac.uk).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 26 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (1): 258–262.
Article history
Received:
September 26 2012
Citation
Jameel M. Inal, Ephraim A. Ansa-Addo, Sigrun Lange; Interplay of host–pathogen microvesicles and their role in infectious disease. Biochem Soc Trans 1 February 2013; 41 (1): 258–262. doi: https://doi.org/10.1042/BST20120257
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.