The paracrine theory has recently changed the view of the biological action of stem cells and of the subsequent potential application of stem cells in regenerative medicine. Indeed, most of the beneficial effects of stem-cell-based therapy have been attributed to soluble factors released from stem cells. In this context, MVs (microvesicles) released as exosomes from the endosomal compartment, or as shedding vesicles from the cell surface, may play a relevant role in the intercellular communication between stem and injured cells. By transferring proteins, bioactive lipids, mRNA and microRNA, MVs act as vehicles of information that may lead to alteration of the phenotype of recipient cells. The exchange of information between stem cells and tissue-injured cells is reciprocal. The MV-mediated transfer of tissue-specific information from the injured cells to stem cells may reprogramme the latter to gain phenotypic and functional characteristics of the cell of origin. On the other hand, MVs released from stem cells may confer a stem-cell-like phenotype to injured cells, with the consequent activation of self-regenerative programmes. In fact, MVs released from stem cells retain several biological activities that are able to reproduce the beneficial effects of stem cells in a variety of experimental models.
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Conference Article|
January 29 2013
Role of stem-cell-derived microvesicles in the paracrine action of stem cells
Giovanni Camussi;
1Department of Internal Medicine and Molecular Biotechnology Center, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
2To whom correspondence should be addressed (email[email protected]).
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Maria Chiara Deregibus;
Maria Chiara Deregibus
1
1Department of Internal Medicine and Molecular Biotechnology Center, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
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Vincenzo Cantaluppi
Vincenzo Cantaluppi
1
1Department of Internal Medicine and Molecular Biotechnology Center, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
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Publisher: Portland Press Ltd
Received:
July 25 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (1): 283–287.
Article history
Received:
July 25 2012
Citation
Giovanni Camussi, Maria Chiara Deregibus, Vincenzo Cantaluppi; Role of stem-cell-derived microvesicles in the paracrine action of stem cells. Biochem Soc Trans 1 February 2013; 41 (1): 283–287. doi: https://doi.org/10.1042/BST20120192
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