Every living cell is covered with a dense and complex array of covalently attached sugars or sugar chains. The majority of these glycans are linked to proteins via the so-called glycosylation process. Protein glycosylation is found in all three domains of life: Eukarya, Bacteria and Archaea. However, on the basis of the limit in analytic tools for glycobiology and genetics in Archaea, only in the last few years has research on archaeal glycosylation pathways started mainly in the Euryarchaeota Haloferax volcanii, Methanocaldococcus maripaludis and Methanococcus voltae. Recently, major steps of the crenarchaeal glycosylation process of the thermoacidophilic archaeon Sulfolobus acidocaldarius have been described. The present review summarizes the proposed N-glycosylation pathway of S. acidocaldarius, describing the phenotypes of the mutants disrupted in N-glycan biosynthesis as well as giving insights into the archaeal O-linked and glycosylphosphatidylinositol anchor glycosylation process.
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Conference Article|
January 29 2013
Hot and sweet: protein glycosylation in Crenarchaeota
Benjamin H. Meyer;
Benjamin H. Meyer
1Molecular Biology of Archaea, Max-Planck Institute for terrestrial Microbiology, Karl-von-Frisch-Strasse 10, 35043 Marburg, Germany
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Sonja-Verena Albers
Sonja-Verena Albers
1
1Molecular Biology of Archaea, Max-Planck Institute for terrestrial Microbiology, Karl-von-Frisch-Strasse 10, 35043 Marburg, Germany
1To whom correspondence should be addressed (email[email protected]).
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Publisher: Portland Press Ltd
Received:
October 30 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (1): 384–392.
Article history
Received:
October 30 2012
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A correction has been published:
Hot and sweet: protein glycosylation in Crenarchaeota
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Benjamin H. Meyer, Sonja-Verena Albers; Hot and sweet: protein glycosylation in Crenarchaeota. Biochem Soc Trans 1 February 2013; 41 (1): 384–392. doi: https://doi.org/10.1042/BST20120296
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