Archaeal viruses, especially viruses that infect hyperthermophilic archaea of the phylum Crenarchaeota, constitute one of the least understood parts of the virosphere. However, owing to recent substantial research efforts by several groups, archaeal viruses are starting to gradually reveal their secrets. In the present review, we summarize the current knowledge on one of the emerging model systems for studies on crenarchaeal viruses, the Rudiviridae. We discuss the recent advances towards understanding the function and structure of the proteins encoded by the rudivirus genomes, their role in the virus life cycle, and outline the directions for further research on this model system. In addition, a revised genome annotation of SIRV2 (Sulfolobus islandicus rod-shaped virus 2) is presented. Future studies on archaeal viruses, combined with the knowledge on viruses of bacteria and eukaryotes, should lead to a better global understanding of the diversity and evolution of virus–host interactions in the viral world.
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February 2013
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Conference Article|
January 29 2013
Genomics and biology of Rudiviruses, a model for the study of virus–host interactions in Archaea
David Prangishvili;
David Prangishvili
1
*Institut Pasteur, Department of Microbiology, 25 rue du Dr. Roux, Paris 75015, France
1To whom correspondence should be addressed (email[email protected]).
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Eugene V. Koonin;
Eugene V. Koonin
†National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, U.S.A.
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Mart Krupovic
Mart Krupovic
*Institut Pasteur, Department of Microbiology, 25 rue du Dr. Roux, Paris 75015, France
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Publisher: Portland Press Ltd
Received:
November 13 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (1): 443–450.
Article history
Received:
November 13 2012
Citation
David Prangishvili, Eugene V. Koonin, Mart Krupovic; Genomics and biology of Rudiviruses, a model for the study of virus–host interactions in Archaea. Biochem Soc Trans 1 February 2013; 41 (1): 443–450. doi: https://doi.org/10.1042/BST20120313
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