In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions. In the present paper, we review recent advances regarding the regulation of ionotropic glutamate receptor trafficking and function by palmitoylation.
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Conference Article|
January 29 2013
Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners
Gareth M. Thomas;
Gareth M. Thomas
1
*Shriners Hospital Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University Medical School, 3500 N. Broad Street, Philadelphia, PA 19130, U.S.A.
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Richard L. Huganir
Richard L. Huganir
1
†Solomon H. Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Hunterian 1001, 725 N Wolfe Street, Baltimore, MD 21205, U.S.A.
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Publisher: Portland Press Ltd
Received:
September 05 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (1): 72–78.
Article history
Received:
September 05 2012
Citation
Gareth M. Thomas, Richard L. Huganir; Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners. Biochem Soc Trans 1 February 2013; 41 (1): 72–78. doi: https://doi.org/10.1042/BST20120223
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