mTORC1 (mammalian target of rapamycin complex 1) is activated by nutrients, growth factors and certain hormones. Signalling downstream of mTORC1 promotes protein synthesis by both activating the processes of translation initiation and elongation, in the short term, and the production of new ribosomes, in the longer term. mTORC1 signalling stimulates the translation of the mRNAs encoding the ribosomal proteins, activates RNA polymerases I and III, which make the rRNAs, and promotes the processing of the precursor for the main rRNAs. Taken together, these effects allow mTORC1 signalling to drive cell growth and proliferation.
Conference Article| July 18 2013
mTORC1 regulates the efficiency and cellular capacity for protein synthesis
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Christopher G. Proud; mTORC1 regulates the efficiency and cellular capacity for protein synthesis. Biochem Soc Trans 1 August 2013; 41 (4): 923–926. doi: https://doi.org/10.1042/BST20130036
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