Actinomycetes are prolific producers of natural products with a wide range of biological activities. Many of the compounds that they make (and derivatives thereof) are used extensively in medicine, most notably as clinically important antibiotics, and in agriculture. Moreover, these organisms remain a source of novel and potentially useful molecules, but maximizing their biosynthetic potential requires a better understanding of natural product biosynthesis. Recent developments in genome sequencing have greatly facilitated the identification of natural product biosynthetic gene clusters. In the present article, I summarize the recent contributions of our laboratory in applying genomic technologies to better understand and manipulate natural product biosynthesis in a range of different actinomycetes.
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December 2013
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Conference Article|
November 20 2013
Understanding and manipulating antibiotic production in actinomycetes
Mervyn J. Bibb
Mervyn J. Bibb
1
*Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
1email[email protected]
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Publisher: Portland Press Ltd
Received:
September 04 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (6): 1355–1364.
Article history
Received:
September 04 2013
Citation
Mervyn J. Bibb; Understanding and manipulating antibiotic production in actinomycetes. Biochem Soc Trans 1 December 2013; 41 (6): 1355–1364. doi: https://doi.org/10.1042/BST20130214
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