Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health and resilience to oxidative stress, particularly in the context of neurodegenerative disease, which is characterized by progressive dysfunction and loss of neurons specifically, and in which oxidative stress is considered a central aetiological contributor. Biological factors which may influence neuronal susceptibility to oxidative stress, in normal and neurodegenerative contexts, are reviewed in the present article, with a focus on properties intrinsic to the neuronal cell type and on properties related to neuronal reliance on surrounding astrocytes.
Conference Article| November 20 2013
Insight into a neuron's preferential susceptibility to oxidative stress
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Karen F.S. Bell; Insight into a neuron's preferential susceptibility to oxidative stress. Biochem Soc Trans 1 December 2013; 41 (6): 1541–1545. doi: https://doi.org/10.1042/BST20130245
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