Neuroimmune networks and the brain endocannabinoid system contribute to the maintenance of neurogenesis. Activation of cannabinoid receptors suppresses chronic inflammatory responses through the attenuation of pro-inflammatory mediators. Moreover, the endocannabinoid system directs cell fate specification of NSCs (neural stem cells) in the CNS (central nervous sytem). The aim of our work is to understand better the relationship between the endocannabinoid and the IL-1β (interleukin-1β) associated signalling pathways and NSC biology, in order to develop therapeutical strategies on CNS diseases that may facilitate brain repair. NSCs express functional CB1 and CB2 cannabinoid receptors, DAGLα (diacylglycerol lipase α) and the NSC markers SOX-2 and nestin. We have investigated the role of CB1 and CB2 cannabinoid receptors in the control of NSC proliferation and in the release of immunomodulators [IL-1β and IL-1Ra (IL-1 receptor antagonist)] that control NSC fate decisions. Pharmacological blockade of CB1 and/or CB2 cannabinoid receptors abolish or decrease NSC proliferation, indicating a critical role for both CB1 and CB2 receptors in the proliferation of NSC via IL-1 signalling pathways. Thus the endocannabinoid system, which has neuroprotective and immunomodulatory actions mediated by IL-1 signalling cascades in the brain, could assist the process of proliferation and differentiation of embryonic or adult NSCs, and this may be of therapeutic interest in the emerging field of brain repair.
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December 2013
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Conference Article|
November 20 2013
Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling
Daniel García-Ovejero;
Daniel García-Ovejero
*Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Parapléjicos (SESCAM), 45071 Toledo, Spain
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Ángel Arévalo-Martín;
Ángel Arévalo-Martín
*Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Parapléjicos (SESCAM), 45071 Toledo, Spain
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Beatriz Navarro-Galve;
Beatriz Navarro-Galve
*Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Parapléjicos (SESCAM), 45071 Toledo, Spain
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Emmanuel Pinteaux;
Emmanuel Pinteaux
†Neurosciences, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, U.K.
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Eduardo Molina-Holgado;
Eduardo Molina-Holgado
1
*Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Parapléjicos (SESCAM), 45071 Toledo, Spain
1Correspondence may be addressed to either of these authors (email[email protected] or [email protected]).
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Francisco Molina-Holgado
Francisco Molina-Holgado
1
‡Neural Stem Cell Laboratory, Department of Life Sciences, Health Sciences Research Centre, University of Roehampton, London SW15 4JD, U.K.
1Correspondence may be addressed to either of these authors (email[email protected] or [email protected]).
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Publisher: Portland Press Ltd
Received:
August 10 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (6): 1577–1582.
Article history
Received:
August 10 2013
Citation
Daniel García-Ovejero, Ángel Arévalo-Martín, Beatriz Navarro-Galve, Emmanuel Pinteaux, Eduardo Molina-Holgado, Francisco Molina-Holgado; Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling. Biochem Soc Trans 1 December 2013; 41 (6): 1577–1582. doi: https://doi.org/10.1042/BST20130198
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