Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3′→5′ exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex.
Conference Article| January 23 2014
mRNA deadenylation by Pan2–Pan3
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Jana Wolf, Lori A. Passmore; mRNA deadenylation by Pan2–Pan3. Biochem Soc Trans 1 February 2014; 42 (1): 184–187. doi: https://doi.org/10.1042/BST20130211
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