Epithelial layers are integral for many physiological processes and are maintained by intercellular adhesive structures. During disease, these structures can disassemble, leading to breakdown of epithelia. TJs (tight junctions) are one type of intercellular adhesion. Loss of TJs has been linked to the pathogenesis of many diseases. The present review focuses on the role of vesicle trafficking in regulation of TJs, in particular trafficking of the TJ protein occludin. We examine how endocytosis and endosomal recycling modulate occludin localization under steady-state conditions and during stimulated TJ disassembly.
Conference Article| January 23 2014
Tight junction regulation through vesicle trafficking: bringing cells together
Sarah J. Fletcher;
- Views Icon Views
- Share Icon Share
Sarah J. Fletcher, Joshua Z. Rappoport; Tight junction regulation through vesicle trafficking: bringing cells together. Biochem Soc Trans 1 February 2014; 42 (1): 195–200. doi: https://doi.org/10.1042/BST20130162
Download citation file: