MLCP (myosin light chain phosphatase) regulates platelet function through its ability to control myosin IIa phosphorylation. Recent evidence suggests that MLCP is a de facto target for signalling events stimulated by cAMP. In the present mini-review, we discuss the mechanisms by which cAMP signalling maintains MLCP in an active state to control platelet contractile machinery.
Conference Article| March 20 2014
Platelet myosin light chain phosphatase: keeping it together
Ahmed Aburima 1
*Thrombosis Research Laboratory, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, U.K.
1To whom correspondence should be addressed (email@example.com).
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Khalid M. Naseem
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Ahmed Aburima, Khalid M. Naseem; Platelet myosin light chain phosphatase: keeping it together. Biochem Soc Trans 1 April 2014; 42 (2): 279–283. doi: https://doi.org/10.1042/BST20130277
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