A number of bacterial glyoxalase I enzymes are maximally activated by Ni2+ and Co2+ ions, but are inactive in the presence of Zn2+, yet these enzymes will also bind this metal ion. The structure–activity relationships between these two classes of glyoxalase I serve as important clues as to how the molecular structures of these proteins control metal-activation profiles.
Conference Article| March 20 2014
Bacterial glyoxalase I enzymes: structural and biochemical investigations
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John F. Honek; Bacterial glyoxalase I enzymes: structural and biochemical investigations. Biochem Soc Trans 1 April 2014; 42 (2): 479–484. doi: https://doi.org/10.1042/BST20130285
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