Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications. Therefore such acetylation modifications might be coupled to the intracellular availability of acetyl-CoA. In the present article, we summarize recent evidence suggesting that the particular protein acetylation modifications enable the regulation of protein function in tune with acetyl-CoA availability and thus the metabolic state of the cell.
Conference Article| August 11 2014
Protein acetylation as a means to regulate protein function in tune with metabolic state
Benjamin P. Tu
*Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, U.S.A.
2To whom correspondence should be addressed (firstname.lastname@example.org).
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Lei Shi, Benjamin P. Tu; Protein acetylation as a means to regulate protein function in tune with metabolic state. Biochem Soc Trans 1 August 2014; 42 (4): 1037–1042. doi: https://doi.org/10.1042/BST20140135
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