STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most of these proteins are regulated by signalling pathways through post-translational modifications, such as phosphorylation and arginine methylation. These proteins share a highly conserved RNA-binding domain, denoted STAR domain. Structural investigations of this STAR domain in complex with RNA have highlighted how a subset of STAR proteins specifically recognizes its RNA targets. The present review focuses on the structural basis of RNA recognition by this family of proteins.
Conference Article| August 11 2014
Structural investigations of the RNA-binding properties of STAR proteins
Cyril Dominguez 1
*Department of Biochemistry, Henry Wellcome Laboratories of Structural Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
1To whom correspondence should be addressed (firstname.lastname@example.org).
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Mikael Feracci, Jaelle Foot, Cyril Dominguez; Structural investigations of the RNA-binding properties of STAR proteins. Biochem Soc Trans 1 August 2014; 42 (4): 1141–1146. doi: https://doi.org/10.1042/BST20140081
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