miRNAs are small, endogenous, post-transcriptional regulators of gene expression. AKI (acute kidney injury) of various aetiologies, including trauma, sepsis and IRI (ischaemia/reperfusion injury) in the context of kidney transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G2/M cell cycle arrest of PTCs and AKI. Recent findings from our laboratory and others presented in this review implicate miRNA regulation of the cell cycle in the pathology of AKI.
Acute kidney injury: a paradigm for miRNA regulation of the cell cycle
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Usman Khalid, Timothy Bowen, Donald J. Fraser, Robert H. Jenkins; Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochem Soc Trans 1 August 2014; 42 (4): 1219–1223. doi: https://doi.org/10.1042/BST20140093
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