Activating as well as inhibitory circuits tightly regulate T-cell activation thresholds and effector differentiation processes enabling proper immune response outcomes. Recently, an additional molecular link between T-cell receptor signalling and CD4+ Th17 cell skewing has been reported, namely that protein kinase C (PKC) θ critically regulates Th17/Th1 phenotypic differentiation and plasticity in CD4+ T-cells by selectively acting as a ‘reprogramming element’ that suppresses Th1-typical genes during Th17-mediated immune activation in order to stabilize a Th17 cell phenotype.
Conference Article| November 17 2014
Protein kinase Cθ: the pleiotropic T-cell signalling intermediate
Gottfried Baier 1
*Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Strasse 1a, A-6020 Innsbruck, Austria
1To whom correspondence should be addressed (emailGottfried.Baier@i-med.ac.at).
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Katarzyna Wachowicz, Gottfried Baier; Protein kinase Cθ: the pleiotropic T-cell signalling intermediate. Biochem Soc Trans 1 December 2014; 42 (6): 1512–1518. doi: https://doi.org/10.1042/BST20140179
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