Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis failure is commonly associated with aneuploidy and aggressive tumours. Protein kinase Cε (PKCε) is a lipid-activated serine/threonine kinase that is part of the PKC superfamily. PKCε plays a complex role in the regulation of migration, adhesion and cytokinesis and in the present article we discuss the interplay between these processes. Integrin-mediated interaction with the actin cytoskeleton is a known regulator of cell adhesion and migration and there is emerging evidence that this pathway may also be essential for cytokinesis. We discuss evidence that a known actin-binding region in PKCε is involved in PKCε-mediated regulation of cytokinesis, providing a link between integrin-mediated stabilization of the cytokinesis furrow and PKCε recruitment.
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Conference Article| November 17 2014
Regulation of the cytokinesis cleavage furrow by PKCε
Peter Parker 1
*Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, U.K.
†Division of Cancer Studies King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, U.K.
1To whom correspondence should be addressed (email@example.com).
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Nicola Brownlow, Tanya Pike, Victoria Crossland, Jeroen Claus, Peter Parker; Regulation of the cytokinesis cleavage furrow by PKCε. Biochem Soc Trans 1 December 2014; 42 (6): 1534–1537. doi: https://doi.org/10.1042/BST20140240
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