miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review, we aim to describe the effect of miRNAs in post-ischaemic repair. First, we describe the miRNAs reported in ischaemic diseases and in angiogenesis. Then we examine their capacity to modulate the behaviour of stem and progenitor cells which could be utilized for vascular repair. And finally we discuss the potential of miRNAs as new clinical biomarkers and therapeutic targets.
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Conference Article| November 17 2014
miRNAs in post-ischaemic angiogenesis and vascular remodelling
Costanza Emanueli 1
*Bristol Heart Institute, School of Clinical Sciences, Bristol Royal Infirmary-Level 7, University of Bristol, Bristol BS2 8HW, U.K.
†National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, U.K.
1To whom correspondence should be addressed (emailCostanza.Emanueli@bristol.ac.uk).
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Jaimy Saif, Costanza Emanueli; miRNAs in post-ischaemic angiogenesis and vascular remodelling. Biochem Soc Trans 1 December 2014; 42 (6): 1629–1636. doi: https://doi.org/10.1042/BST20140263
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