Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.
Conference Article| November 17 2014
The glioblastoma vasculature as a target for cancer therapy
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Anna Dimberg; The glioblastoma vasculature as a target for cancer therapy. Biochem Soc Trans 1 December 2014; 42 (6): 1647–1652. doi: https://doi.org/10.1042/BST20140278
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