The biophysical, mechanical and chemical characteristics of extracellular matrixes influence many cellular functions to control tissue homoeostasis and drive progression of cancer and inflammatory diseases. To maintain normal tissue function, fibronectin-rich matrixes are subject to dynamic cell-mediated structural and chemical modification. In this article, we discuss how localized application of mechanical force, heterodimer-specific integrin engagement and matrix proteolysis regulate fibronectin assembly and turnover. We also speculate that recently identified integrin trafficking, syndecan signalling and adhesion receptor–growth factor receptor cross-talk mechanisms might dynamically control the function, assembly and mechanical properties of a viable, and mechanoresponsive, fibronectin network.
Conference Article| January 26 2015
Fibronectin remodelling: cell-mediated regulation of the microenvironment
Katarzyna I. Wolanska;
Mark R. Morgan
Mark R. Morgan 1
*Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Nuffield Building, Crown Street, Liverpool L69 3BX, U.K.
1To whom correspondence should be addressed (email@example.com).
Search for other works by this author on:
- Views Icon Views
- Share Icon Share
Katarzyna I. Wolanska, Mark R. Morgan; Fibronectin remodelling: cell-mediated regulation of the microenvironment. Biochem Soc Trans 1 February 2015; 43 (1): 122–128. doi: https://doi.org/10.1042/BST20140313
Download citation file: