The cytoskeleton is utilized for a variety of cellular processes, including migration, endocytosis and adhesion. The required molecular components are often shared between different processes, but it is not well understood how the cells balance their use. We find that macropinocytosis and cell migration are negatively correlated. Heavy drinkers move only slowly and vice versa, fast cells do not take big gulps. Both processes are balanced by the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3). Elevated PIP3 signalling causes a shift towards macropinocytosis and inhibits motility by redirecting the SCAR/WAVE complex, a major nucleator of actin filaments. High resolution microscopy shows that patches with high levels of PIP3 recruit SCAR/WAVE on their periphery, resulting in circular ruffle formation and engulfment. Results shed new light on the role of PIP3, which is commonly thought to promote cell motility.
Conference Article| January 26 2015
Drink or drive: competition between macropinocytosis and cell migration
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
Douwe M. Veltman; Drink or drive: competition between macropinocytosis and cell migration. Biochem Soc Trans 1 February 2015; 43 (1): 129–132. doi: https://doi.org/10.1042/BST20140251
Download citation file: