Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals, are needed to demonstrate the role of pannexins in various cellular functions. This review focuses on the known roles of Panx1 related to purinergic signalling in the vasculature focusing on post-translational modifications and channel gating mechanisms that may participate in the regulated release of ATP.
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June 2015
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Conference Article|
June 01 2015
Emerging concepts regarding pannexin 1 in the vasculature
Miranda E. Good;
Miranda E. Good
*Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
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Daniela Begandt;
Daniela Begandt
*Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
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Leon J. DeLalio;
Leon J. DeLalio
*Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
†Department of Pharmacology, University of Virginia, Charlottesville, VA, U.S.A.
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Alexander S. Keller;
Alexander S. Keller
*Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
†Department of Pharmacology, University of Virginia, Charlottesville, VA, U.S.A.
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Marie Billaud;
Marie Billaud
‡Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, U.S.A.
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Brant E. Isakson
Brant E. Isakson
1
*Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
§Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
1To whom correspondence should be addressed (emailbrant@virginia.edu).
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Biochem Soc Trans (2015) 43 (3): 495–501.
Article history
Received:
February 10 2015
Citation
Miranda E. Good, Daniela Begandt, Leon J. DeLalio, Alexander S. Keller, Marie Billaud, Brant E. Isakson; Emerging concepts regarding pannexin 1 in the vasculature. Biochem Soc Trans 1 June 2015; 43 (3): 495–501. doi: https://doi.org/10.1042/BST20150045
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