Tribbles (TRIB) proteins, a family of evolutionary conserved psuedokinase proteins, modulate various signalling pathways within the cell. The regulatory roles of TRIB make them an important part of a number of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte by spermatozoon and lasts throughout early embryonic development, pregnancy and labour. Therefore, there is a close cooperation between the reproductive system and the innate immune system. Evidence from our lab has demonstrated that improper activation of the innate immune system can reduce embryo implantation, thus leading to infertility. Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events.
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Review Article| October 09 2015
Tribbles role in reproduction
Shaghayegh Basatvat ;
Deborah Angela Louise Carter ;
Endre Kiss-Toth ;
Alireza Fazeli 1
*Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, The Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, U.K.
1To whom correspondence should be addressed (firstname.lastname@example.org).
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Shaghayegh Basatvat, Deborah Angela Louise Carter, Endre Kiss-Toth, Alireza Fazeli; Tribbles role in reproduction. Biochem Soc Trans 1 October 2015; 43 (5): 1116–1121. doi: https://doi.org/10.1042/BST20150121
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