Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.
Oncosuppressive functions of tribbles pseudokinase 3
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María Salazar, Mar Lorente, Alba Orea-Soufi, David Dávila, Tatiana Erazo, José Lizcano, Arkaitz Carracedo, Endre Kiss-Toth, Guillermo Velasco; Oncosuppressive functions of tribbles pseudokinase 3. Biochem Soc Trans 1 October 2015; 43 (5): 1122–1126. doi: https://doi.org/10.1042/BST20150124
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