Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For many natural repeat-proteins, it has been shown that weak energetic links between repeats lead to the breakdown of co-operativity and the appearance of folding sub-domains within an apparently regular repeat array. The quasi-1D architecture of repeat-proteins is crucial in detailing how the local energetic balances can modulate the folding dynamics of these proteins, which can be related to the physiological behaviour of these ubiquitous biological systems.
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October 2015
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Review Article|
October 09 2015
Repeat proteins challenge the concept of structural domains
Rocío Espada;
Rocío Espada
1
*Protein Physiology Lab, Dep de Química Biológica, Facultad de Ciencias Exactas y Naturales, UBA-CONICET-IQUIBICEN, Buenos Aires, C1430EGA, Argentina
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R. Gonzalo Parra;
R. Gonzalo Parra
1
*Protein Physiology Lab, Dep de Química Biológica, Facultad de Ciencias Exactas y Naturales, UBA-CONICET-IQUIBICEN, Buenos Aires, C1430EGA, Argentina
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Manfred J. Sippl;
Manfred J. Sippl
†Center of Applied Molecular Engineering, Division of Bioinformatics, Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
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Thierry Mora;
Thierry Mora
‡Laboratoire de physique statistique, CNRS, UPMC and Ecole normale supérieure, 24 rue Lhomond, 75005 Paris, France
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Aleksandra M. Walczak;
Aleksandra M. Walczak
§Laboratoire de physique théorique, CNRS, UPMC and Ecole normale supérieure, 24 rue Lhomond, 75005 Paris, France
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Diego U. Ferreiro
Diego U. Ferreiro
2
*Protein Physiology Lab, Dep de Química Biológica, Facultad de Ciencias Exactas y Naturales, UBA-CONICET-IQUIBICEN, Buenos Aires, C1430EGA, Argentina
2To whom correspondence should be addressed (email[email protected]).
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Publisher: Portland Press Ltd
Received:
April 21 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 844–849.
Article history
Received:
April 21 2015
Citation
Rocío Espada, R. Gonzalo Parra, Manfred J. Sippl, Thierry Mora, Aleksandra M. Walczak, Diego U. Ferreiro; Repeat proteins challenge the concept of structural domains. Biochem Soc Trans 1 October 2015; 43 (5): 844–849. doi: https://doi.org/10.1042/BST20150083
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