Cofactor engineering has been long identified as a valuable tool for metabolic engineering. Besides interventions targeting the pools of redox cofactors, many studies addressed the adenosine pools of microorganisms. In this mini-review, we discuss interventions that manipulate the availability of ATP with a special focus on ATP wasting strategies. We discuss the importance to fine-tune the ATP yield along a production pathway to balance process performance parameters like product yield and volumetric productivity.
Review Article| November 27 2015
Manipulation of the ATP pool as a tool for metabolic engineering
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Oliver Hädicke, Steffen Klamt; Manipulation of the ATP pool as a tool for metabolic engineering. Biochem Soc Trans 1 December 2015; 43 (6): 1140–1145. doi: https://doi.org/10.1042/BST20150141
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