Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5)P3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins(1,3,4)P3. This article recalls my entanglement with these two inositol phosphates.
Review Article| February 09 2016
A tale of two inositol trisphosphates
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Robin Irvine; A tale of two inositol trisphosphates. Biochem Soc Trans 15 February 2016; 44 (1): 202–211. doi: https://doi.org/10.1042/BST20150205
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