The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.
The PTEN protein: cellular localization and post-translational regulation
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
Nick R. Leslie, Nisha Kriplani, Miguel A. Hermida, Virginia Alvarez-Garcia, Helen M. Wise; The PTEN protein: cellular localization and post-translational regulation. Biochem Soc Trans 15 February 2016; 44 (1): 273–278. doi: https://doi.org/10.1042/BST20150224
Download citation file: