Inositol polyphosphate multikinase (IPMK, ipk2, Arg82, ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein–protein interactions (PPIs). By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a few recent discoveries that have shed more light on the role IPMK plays in inositide metabolism, nuclear signalling and transcriptional regulation.
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
M. Merced Malabanan, Raymond D. Blind; Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism. Biochem Soc Trans 15 February 2016; 44 (1): 279–285. doi: https://doi.org/10.1042/BST20150225
Download citation file: