Mitochondria depend on a tightly regulated supply of phospholipids. The protein of relevant evolutionary and lymphoid interest (PRELI)/Ups1 family together with its mitochondrial chaperones [TP53-regulated inhibitor of apoptosis 1 (TRIAP1)/Mdm35] represents a unique heterodimeric lipid-transfer system that is evolutionary conserved from yeast to man. Recent X-ray crystal structures of the human and yeast systems are compared and discuss here and shed new insight into the mechanism of the PRELI/Ups1 system.
Review Article| April 11 2016
Structural comparison of yeast and human intra-mitochondrial lipid transport systems
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Xeni Miliara, Stephen Matthews; Structural comparison of yeast and human intra-mitochondrial lipid transport systems. Biochem Soc Trans 15 April 2016; 44 (2): 479–485. doi: https://doi.org/10.1042/BST20150264
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