Although the measurement of triacylglycerols (TAGs) by clinical chemistry has been used in the diagnosis of a range of metabolic diseases, such approaches ignore the different species of TAGs that contribute to the total concentration. With the advent of LC and direct infusion forms of MS it is now possible to profile the individual TAGs in blood plasma or tissue extracts. This mini review surveys the information that is obtainable from the lipidomic profiling of TAGs in following metabolic diseases such as type 2 diabetes (T2DM), cardiovascular disease (CVD) and non-alcoholic fatty liver disease, as well as the development of insulin resistance and obesity.
Review Article| April 11 2016
Blood triacylglycerols: a lipidomic window on diet and disease
Julian L. Griffin
Julian L. Griffin 1
*Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, U.K.
†Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org; email@example.com).
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Francis Sanders, Ben McNally, Julian L. Griffin; Blood triacylglycerols: a lipidomic window on diet and disease. Biochem Soc Trans 15 April 2016; 44 (2): 638–644. doi: https://doi.org/10.1042/BST20150235
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