Virtually all the biological processes that occur inside or outside cells are mediated by protein–protein interactions (PPIs). Hence, the charting and description of the PPI network, initially in organisms, the interactome, but more recently in specific tissues, is essential to fully understand cellular processes both in health and disease. The study of PPIs is also at the heart of renewed efforts in the medical and biotechnological arena in the quest of new therapeutic targets and drugs. Here, we present a mini review of 11 computational tools and resources tools developed by us to address different aspects of PPIs: from interactome level to their atomic 3D structural details. We provided details on each specific resource, aims and purpose and compare with equivalent tools in the literature. All the tools are presented in a centralized, one-stop, web site: InteractoMIX (http://interactomix.com).
Skip Nav Destination
Article navigation
June 2016
-
Cover Image
Cover Image
Shining a spotlight on outer membrane protein folding. Outer membrane proteins (OMPs) [such as OmpA (green, top left)] have to navigate their way from the ribosome (bottom of image) via trigger factor (red) and SecB (turquoise), through the SecYEG translocon (red/yellow) in the inner membrane (IM). They are then chaperoned across the periplasm until they can insert and fold into their ultimate destination, the outer membrane. For further details see pp. 802–809. The figure was produced by Jim Horne. - PDF Icon PDF LinkTable of Contents
Review Article|
June 09 2016
InteractoMIX: a suite of computational tools to exploit interactomes in biological and clinical research
Daniel Poglayen;
Daniel Poglayen
1
*Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona 08005, Catalonia, Spain
Search for other works by this author on:
Manuel Alejandro Marín-López;
Manuel Alejandro Marín-López
1
*Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona 08005, Catalonia, Spain
Search for other works by this author on:
Jaume Bonet;
Jaume Bonet
1
*Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona 08005, Catalonia, Spain
†Laboratory of Protein Design & Immunoengineering, School of Engineering, Ecole Polytechnique Federale de Lausanne, Lausanne 1015, Vaud, Switzerland
Search for other works by this author on:
Oriol Fornes;
Oriol Fornes
*Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona 08005, Catalonia, Spain
‡Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
Search for other works by this author on:
Javier Garcia-Garcia;
Javier Garcia-Garcia
*Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona 08005, Catalonia, Spain
Search for other works by this author on:
Joan Planas-Iglesias;
Joan Planas-Iglesias
§Division of Metabolic and Vascular Health, University of Warwick, Coventry CV4 7AL, U.K.
Search for other works by this author on:
Joan Segura;
Joan Segura
║GN7 of the National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC), Madrid 28049, Spain
Search for other works by this author on:
Baldo Oliva;
Baldo Oliva
2
*Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona 08005, Catalonia, Spain
2Correspondence may be addressed to either of these authors (email [email protected] or [email protected]).
Search for other works by this author on:
Narcis Fernandez-Fuentes
Narcis Fernandez-Fuentes
2
¶Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3DA, U.K.
2Correspondence may be addressed to either of these authors (email [email protected] or [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
December 11 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 Authors; published by Portland Press Limited
2016
Biochem Soc Trans (2016) 44 (3): 917–924.
Article history
Received:
December 11 2015
Citation
Daniel Poglayen, Manuel Alejandro Marín-López, Jaume Bonet, Oriol Fornes, Javier Garcia-Garcia, Joan Planas-Iglesias, Joan Segura, Baldo Oliva, Narcis Fernandez-Fuentes; InteractoMIX: a suite of computational tools to exploit interactomes in biological and clinical research. Biochem Soc Trans 15 June 2016; 44 (3): 917–924. doi: https://doi.org/10.1042/BST20150001
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Get Email Alerts
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |