A relatively well-understood multistep process enables mutation-bearing cells to form primary tumours, which later use the circulation system to colonize new locations and form metastases. However, in which way the emerging abundance of different non-coding RNAs supports tumour progression is poorly understood. Here, we review new lines of evidence linking long and short types of non-coding RNAs to signalling pathways activated in the course of cancer progression by growth factors and by the tumour micro-environment. Resolving the new dimension of non-coding RNAs in oncogenesis will probably translate to earlier detection of cancer and improved therapeutic strategies.
Review Article| February 15 2017
The short and the long: non-coding RNAs and growth factors in cancer progression
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Aldema Sas-Chen, Swati Srivastava, Yosef Yarden; The short and the long: non-coding RNAs and growth factors in cancer progression. Biochem Soc Trans 8 February 2017; 45 (1): 51–64. doi: https://doi.org/10.1042/BST20160131
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