Endosomal adaptor proteins are important regulators of signaling pathways underlying many biological processes. These adaptors can integrate signals from multiple pathways via localization to specific endosomal compartments, as well as through multiple protein–protein interactions. One such adaptor protein that has been implicated in regulating signaling pathways is the adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif 1 (APPL1). APPL1 localizes to a subset of Rab5-positive endosomes through its Bin–Amphiphysin–Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent work into the function of APPL1 in cell migration and adhesion.
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Review Article| June 15 2017
APPL1 is a multifunctional endosomal signaling adaptor protein
Nicole L. Diggins;
Donna J. Webb
1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, U.S.A.
2Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, U.S.A.
3Department of Cancer Biology, Vanderbilt University, Nashville, TN 37235, U.S.A.
Correspondence: Donna J. Webb (firstname.lastname@example.org)
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Nicole L. Diggins, Donna J. Webb; APPL1 is a multifunctional endosomal signaling adaptor protein. Biochem Soc Trans 15 June 2017; 45 (3): 771–779. doi: https://doi.org/10.1042/BST20160191
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