Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis. Loss of Sdc1 in mice is a gain-of-function mutation that significantly decreases the susceptibility to several bacterial infections, suggesting that subversion of Sdc1 is an important virulence strategy. HS glycosaminoglycan (GAG) chains of cell surface Sdc1 promote bacterial pathogenesis by facilitating the attachment of bacteria to host cells. Engagement of cell surface Sdc1 HS chains by bacterial adhesins transmits signal through the highly conserved Sdc1 cytoplasmic domain, which can lead to uptake of intracellular bacterial pathogens. On the other hand, several bacteria that do not require Sdc1 for their attachment and invasion stimulate Sdc1 shedding and exploit the capacity of Sdc1 ectodomain HS GAGs to disarm innate defense mechanisms to evade immune clearance. Recent data suggest that select HS sulfate motifs, and not the overall charge of HS, are important in the inhibition of innate immune mechanisms. Here, we discuss several examples of Sdc1 subversion in bacterial infections.
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April 2018
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A 3D rendering of a Ubiquitin protein molecule. In this issue of Biochemical Society Transactions, Ovaa and Vertegaal discuss the role of ubiquitination and SUMO proteins in conjugation and deconjugation machineries; for details, see pages 423–436.
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March 09 2018
Glycobiology of syndecan-1 in bacterial infections
Rafael S. Aquino;
Rafael S. Aquino
1Division of Respiratory Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, U.S.A.
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Yvonne Hui-Fang Teng;
Yvonne Hui-Fang Teng
1Division of Respiratory Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, U.S.A.
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Pyong Woo Park
1Division of Respiratory Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, U.S.A.
2Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, U.S.A.
Correspondence: Pyong Woo Park ([email protected])
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Publisher: Portland Press Ltd
Received:
January 03 2018
Revision Received:
January 19 2018
Accepted:
January 26 2018
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Biochem Soc Trans (2018) 46 (2): 371–377.
Article history
Received:
January 03 2018
Revision Received:
January 19 2018
Accepted:
January 26 2018
Citation
Rafael S. Aquino, Yvonne Hui-Fang Teng, Pyong Woo Park; Glycobiology of syndecan-1 in bacterial infections. Biochem Soc Trans 17 April 2018; 46 (2): 371–377. doi: https://doi.org/10.1042/BST20170395
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