Allostery is a fundamental regulatory mechanism in biology. Although generally accepted that it is a dynamics-driven process, the exact molecular mechanism of allosteric signal transmission is hotly debated. We argue that allostery is as a part of a bigger picture that also includes fractal-like properties of protein interior, hierarchical protein folding and entropy-driven molecular recognition. Although so far all these phenomena were studied separately, they stem from the same common root: self-organization of polypeptide chains and, thus, has to be studied collectively. This merge will allow the cross-referencing of a broad spectrum of multi-disciplinary data facilitating progress in all these fields.
Review Article| April 20 2018
Self-organization, entropy and allostery
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Alexandr P. Kornev; Self-organization, entropy and allostery. Biochem Soc Trans 19 June 2018; 46 (3): 587–597. doi: https://doi.org/10.1042/BST20160144
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