Oncogenic mutations in RAS genes underlie the pathogenesis of many human tumours, and there has been intense effort for over 30 years to develop effective and tolerated targeted therapeutics for patients with Ras-driven cancers. This review summarises the progress made in Ras drug discovery, highlighting some of the recent developments in directly targeting Ras through advances in small molecule drug design and novel therapeutic strategies.
Keywords:cancer, drug therapy, RAS
Subjects:Cancer, Pharmacology & Toxicology
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society