The regulation of translation is critical in almost every aspect of gene expression. Nonetheless, the ribosome is historically viewed as a passive player in this process. However, evidence is accumulating to suggest that variations in the ribosome can have an important influence on which mRNAs are translated. Scope for variation is provided via multiple avenues, including heterogeneity at the level of both ribosomal proteins and ribosomal RNAs and their covalent modifications. Together, these variations provide the potential for hundreds, if not thousands, of flavours of ribosome, each of which could have idiosyncratic preferences for the translation of certain messenger RNAs. Indeed, perturbations to this heterogeneity appear to affect specific subsets of transcripts and manifest as cell-type-specific diseases. This review provides a historical perspective of the ribosomal code hypothesis, before outlining the various sources of heterogeneity, their regulation and functional consequences for the cell.
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Review Article| November 12 2018
Ribosomal flavours: an acquired taste for specific mRNAs?
Simon J. Hubbard;
Mark P. Ashe
1School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Michael Smith Building, Oxford Rd., Manchester M13 9PT, U.K.
Correspondence: Mark P. Ashe (firstname.lastname@example.org)
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Christian Bates, Simon J. Hubbard, Mark P. Ashe; Ribosomal flavours: an acquired taste for specific mRNAs?. Biochem Soc Trans 17 December 2018; 46 (6): 1529–1539. doi: https://doi.org/10.1042/BST20180160
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