Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-κB activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles to the lysosome, ubiquitination is also an important component of cell-autonomous immunity. Not surprisingly, several pathogenic bacteria encode deubiquitinases (DUBs) and use them as secreted effectors that prevent ubiquitination of bacterial components. A systematic overview of known bacterial DUBs, including their cleavage specificities and biological roles, suggests multiple independent acquisition events from host-encoded DUBs and other proteases. The widely used classification of DUBs into seven well-defined families should only be applied to eukaryotic DUBs, since several bacterial DUBs do not follow this classification.
Review Article| December 17 2019
Bacterial DUBs: deubiquitination beyond the seven classes
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Thomas Hermanns, Kay Hofmann; Bacterial DUBs: deubiquitination beyond the seven classes. Biochem Soc Trans 20 December 2019; 47 (6): 1857–1866. doi: https://doi.org/10.1042/BST20190526
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