CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of TH17, Foxp3+ T regulatory (Treg) cells, and Type 1 regulatory T (Tr1) cells, supporting a model of ITK signals controlling a decision point in the effector T cell differentiation process.
Tuning T helper cell differentiation by ITK
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Jessica P. Elmore, Michael C. McGee, Natalie F. Nidetz, Orchi Anannya, Weishan Huang, Avery August; Tuning T helper cell differentiation by ITK. Biochem Soc Trans 28 February 2020; 48 (1): 179–185. doi: https://doi.org/10.1042/BST20190486
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