Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way. Those FG-Nups have been demonstrated to participate in various biological processes besides nucleocytoplasmic transport. The high number of accessible hydrophobic motifs of FG-Nups potentially gives rise to this multifunctionality, enabling them to form unique microenvironments. In this review, we discuss the multifunctionality of disordered and F-rich Nups and the diversity of their localizations, emphasizing the important roles of those Nups in various regulatory and metabolic processes.
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The plasma membrane of lymphocytes is highly compartmentalized in so-called nanodomains or protein islands. Proteins such as Caveolin-1 (pink), tetraspanins (blue) or flotillins (violet) define these protein islands and thereby regulate the functioning of the immune system. In this issue (see pages 2387–2397), Schaffer and Minguet discuss the importance of these protein islands regarding lymphocyte activation and the development of immunopathologies. This cover artwork has been created by Susana Minguet.
Review Article|
December 18 2020
Multifunctionality of F-rich nucleoporins
Nike Heinß;
Nike Heinß
*
1Biocentre, Johannes Gutenberg-University Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany
2Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany
3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
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Mikhail Sushkin;
Mikhail Sushkin
*
1Biocentre, Johannes Gutenberg-University Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany
2Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany
3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
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Miao Yu;
Miao Yu
1Biocentre, Johannes Gutenberg-University Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany
2Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany
3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
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Edward A. Lemke
1Biocentre, Johannes Gutenberg-University Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany
2Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany
3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Correspondence: Edward A Lemke (edlemke@uni-mainz.de)
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Biochem Soc Trans (2020) 48 (6): 2603–2614.
Article history
Received:
September 18 2020
Revision Received:
November 13 2020
Accepted:
December 01 2020
Citation
Nike Heinß, Mikhail Sushkin, Miao Yu, Edward A. Lemke; Multifunctionality of F-rich nucleoporins. Biochem Soc Trans 18 December 2020; 48 (6): 2603–2614. doi: https://doi.org/10.1042/BST20200357
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